Current Issue : January - March Volume : 2017 Issue Number : 1 Articles : 7 Articles
Background: DNMT3B polymorphisms are associated with the susceptibility of lung cancer. DNMT3B âË?â??2437T>A is a\nnovel polymorphism, and its influence on the risk of lung cancer in Chinese was investigated in this study. In addition,\neffect of DNMT3B âË?â??149C>T polymorphism on lung cancer was also explored.\nMethods: Genotyping in subjects were performed by PCR-RFLP. Haplotype frequencies were estimated by estimating\nhaplotype software. Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by unconditional\nlogistic regression analysis.\nResults: Neither of the two polymorphisms was correlated with lung cancer (âË?â??149C>T: CT+TT vs CC: OR = 0.78, 95%CI,\n0.57 to 1.05, P = 0.361; âË?â??2437T>A: AT+AA vs TT: OR = 0.99, 95%CI, 0.74 to 1.33, P = 0.168). In stratification\nanalysis, T-allele carrier genotype of âË?â??149C>T polymorphism resulted in a reduced lung cancer risk at stage II,\ncompared with CC (OR = 0.46, 95%CI, 0.28 to 0.77, P = 0.023). In haplotype analysis, when âË?â??149C/âË?â??2437T was\nused as reference, the other combined genotypes of the two polymorphisms had no significant effect on\nlung cancer risk (P > 0.05).\nConclusions: The two DNMT3B polymorphisms are not correlated with lung cancer risk among Chinese\npopulation nor the haplotype of them....
Objective: To describe the primary carcinoma of the retroperitoneum that was positive\nfor human papillomavirus (HPV), a surrogate molecular marker for high-risk\nHPV (p16) and p53. Methods: This is a case report. Results: We report a case of 50-\nyear-old woman with a large retroperitoneal mass (squamous cell carcinoma on histology)\nthat was treated in September of 2014 with radical concurrent chemotherapy\nwith weekly cisplatin and pelvic radiation (4500 cGY) and additional right pelvic\nboost of 900 cGY. It was assumed she had FIGO stage IIIB local advanced cervical\ncancer. She initially presented with the right leg swelling, severe pain and difficulty in\nwalking and was treated with antibiotics for presumed cellulitis. Several months later\nright leg extensive deep vein thrombosis (DVT) was diagnosed and was started on\nanticoagulation. CT scan and MRI reported a large right-sided retroperitoneal mass\noccluding the illiac vessels and ureter. The mass had invaded into the adjacent pelvic\nsidewall, with destruction of the iliacus muscle and underlying iliac wing. MRI\nshowed that the cervix and uterus were both normal. On examination cervix appeared\ngrossly normal and cervical punch biopsy revealed HSIL only. CT-guided biopsy\nof the mass revealed a moderately differentiated squamous cell carcinoma positive\nfor p16 and p53. Conclusion: Primary squamous cell carcinoma of the retroperitoneum\nis a real entity that is unknown. It is unclear if primary neoplasia in the cervix\nwas small from which a cell clone arose and migrated to the retroperitoneal\nspace....
Hypofractionated radiation therapy has proven effective on locoregional control and\ntolerance in the adjuvant treatment of breast cancer. The aim of this study is to\ncompare the results of hypofractionated radiation therapy versus conventional radiation\ntherapy in terms of local control and tolerance. It was a retrospective study of\npatients observations collected from January 2007 to December 2008 in Department\nof Radiation Therapy in Institut National dâ��Oncologie de Rabat. The treatment results\nwere evaluated by the rate of locoregional recurrence, distant recurrence and\nresearch of late toxicities. Radiotherapy was delivered using the same technique in\nboth groups, by gamma photons of cobalt 60 with an energy of 1.25 MeV. They were\n2 groups: the first group treated with standard dose rate and the second group\ntreated by hypofractionated radiation therapy. The mean age of the patients was 42.8\n�± 6.9 years old in the standard group and 43.22 �± 7.2 years old in the hypofractionation\ngroup. We noted a predominance of infiltrating ductal carcinoma. The majority\nof patients were pT2, pN0 and pN1. The majority of patients had radical surgery and\nchemotherapy with anthracyclines in both groups. We noted a statistically significant\ndifference in the irradiation of chest wall between the standard (89.2%) and hypofractionated\ngroup (70.3%), with p = 0.043. The median duration of radiation therapy\nwas statistically different in both groups: 39 days in the standard and 23 days in\nthe hypofractionated group (p < 0.001). The local recurrences were statistically identical\nto 12 and 24 months (p = 0.999). Concerning toxicities, the frequency of adverse\nevent was similar in both groups. Hypofractionated radiation therapy with a total\ndose of 42 Gy at 2.8 Gy per fraction in 5 fractions weekly is comparable to standard\nradiotherapy in terms of local control and tolerance and is therefore a very good alternative\nto standard treatment....
Objectives. Invasion of differentiated thyroid cancer (DTC) into surrounding structures can lead to morbid procedures such as\nlaryngectomy and tracheal resection. In these patients, there is a potential role for neoadjuvant therapy. Methods. We identified\nthree studies involving the treatment of DTC with neoadjuvant chemotherapy: two from Slovenia and one from Japan. Results.\nThese studies demonstrate that in selected situations, neoadjuvant chemotherapy can have a good response and allow for a more\ncomplete surgical resection, the treatment of DTC. Additionally, the SELECT trial shows that the targeted therapy lenvatinib is\neffective in the treatment of DTC and could be useful as neoadjuvant therapy for this disease due to its short time to response.\nPazopanib has also demonstrated promise in phase II data. Conclusions. Thus, chemotherapy in the neoadjuvant setting could\npossibly be useful for managing advanced DTC. Additionally, some of the new tyrosine kinase inhibitors (TKIs) hold promise for\nuse in the neoadjuvant setting in DTC....
Background: Gross target volume of primary tumor (GTV-P) is very important for the prognosis prediction of\npatients with nasopharyngeal carcinoma (NPC), but it is unknown whether the same is true for locally advanced NPC\npatients treated with intensity-modulated radiotherapy (IMRT). This study aimed to clarify the prognostic value of\ntumor volume for patient with locally advanced NPC receiving IMRT and to find a suitable cut-off value of GTV-P for\nprognosis prediction.\nMethods: Clinical data of 358 patients with locally advanced NPC who received IMRT were reviewed. Receiver operating\ncharacteristic (ROC) curves were used to identify the cut-off values of GTV-P for the prediction of different endpoints\n[overall survival (OS), local relapse-free survival (LRFS), distant metastasis-free survival (DMFS), and disease-free\nsurvival (DFS)] and to test the prognostic value of GTV-P when compared with that of the American Joint Committee\non Cancer T staging system.\nResults: The 358 patients with locally advanced NPC were divided into two groups by the cut-off value of GTV-P\nas determined using ROC curves: 219 (61.2%) patients with GTV-P �46.4 mL and 139 (38.8%) with GTV-P >46.4 mL.\nThe 3-year OS, LRFS, DMFS, and DFS rates were all higher in patients with GTV-P �46.4 mL than in those with\nGTV-P > 46.4 mL (all P < 0.05). Multivariate analysis indicated that GTV-P >46.4 mL was an independent unfavorable\nprognostic factor for patient survival. The ROC curve verified that the predictive ability of GTV-P was superior to that of\nT category (P < 0.001). The cut-off values of GTV-P for the prediction of OS, LRFS, DMFS, and DFS were 46.4, 57.9, 75.4\nand 46.4 mL, respectively.\nConclusion: In patients with locally advanced NPC, GTV-P >46.4 mL is an independent unfavorable prognostic indicator\nfor survival after IMRT, with a prognostic value superior to that of T category....
Background.We studied the role of pulmonary veins in cancer progression using computed tomography (CT) scans. Methods. We\nobtained data from 260 patients with pulmonary vein obstruction syndrome (PVOS).We used CT scans to investigate pulmonary\nlesions in relation to pulmonary veins. We divided the lesions into central and peripheral lesions by their anatomical location: in\nthe lung parenchymal tissue or pulmonary vein; in the superior or inferior pulmonary vein; and by unilateral or bilateral presence\nin the lungs. Results. Of the 260 PVOS patients, 226 (87%) had central lesions, 231 (89%) had peripheral lesions, and 190 (75%)\nhad mixed central and peripheral lesions. Among the 226 central lesions, 93% had lesions within the superior pulmonary vein,\neither bilaterally or unilaterally. Among the 231 peripheral lesions, 65% involved bilateral lungs, 70% involved lesions within the\ninferior pulmonary veins, and 23% had obvious metastatic extensions into the left atrium. All patients exhibited nodules within\ntheir pulmonary veins. The predeath status included respiratory failure (40%) and loss of consciousness (60%). Conclusion. CT\nscans play an important role in following tumor progression within pulmonary veins. Besides respiratory distress, PVOS cancer\ncells entering centrally can result in cardiac and cerebral events and loss of consciousness or can metastasize peripherally from the\npulmonary veins to the lungs....
Novel molecular targets are being searched to aid in prostate cancer diagnosis and therapy. Recently, ZFP91 zinc finger protein has\nbeen found to be upregulated in prostate cancer cell lines. It is a potentially important oncogenic protein; however only limited\ndata regarding its biological function and expression patterns are available. To date, ZFP91 has been shown to be a key factor in\nactivation of noncanonical NF-...
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